<p>Heterozygous Genotype rs17580 AT (PiS) in <em>SERPINA1</em> is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case–Control and Populational Study</p>

• DOI: 10.2147/copd.s247446
• Publication Date: 2020-05-26T21:39:25Z
• Authors: Gloria Pérez-Rubio; Enrique Ambrocio-...; Luis A. López-Flores; Ana I. Juárez-Martín; Luis Octavio Jimé...; Susana Zoreque-Ca...; Gustavo Galicia-N...; María Elena Ramír...; Filiberto Cruz-Vi...; Manuel de Jesús C...; Citlaltepetl Sali...; Rafael J Hernánde...; Alejandra Ramírez...; Ramcés Falfán-Val...
• Keywords: Tobacco smoke

The protease inhibitor S (PiS) and Z (PiZ) variants have been stated as the only genetic cause of chronic obstructive pulmonary disease (COPD) in Caucasians. However, its frequency admixed populations is low. We aimed to identify susceptibility between PiS (rs17580) PiZ (rs28929474) polymorphisms with COPD related tobacco smoking biomass-burning smoke well determine frequencies Mestizo Amerindian from Mexico.One thousand eight hundred seventy-eight subjects were included two comparisons cases controls, (1) smokers without (COPD-S, n=399; SWOC, n=1106); (2) Biomass-burning smoke-exposed (COPD-BS, n=98; BBES, n=275). In addition, 2354 Mexican identified Mestizos (n=1952) (n=402) included. population structure was evaluated using 59 informative ancestry markers.The AT genotype rs17580 associated both (COPD-S vs SWOC p<0.001, OR=2.16; COPD-BS BBES p<0.0001, OR=11.50). Mexico-North has a greater Caucasian contribution (54.7%) compared center (46.9%) southeast (42.7%).The rs17580, genotype, Mexican-Mestizo exposed smoke. more frequent North country, which high component.