SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

• DOI: 10.2147/copd.s362467
• Publication Date: 2022-07-18T16:40:12Z
• Authors: Zhifei Hou; Zhihui Yuan; Hao Wang; Kang Chang; Yong Gao
• Keywords: 0301 basic medicine; China; smad4 (similar to mother against decapentaplegic 4) rs10502913; RC705-779; Genotype; International Journal of Chronic Obstructive Pulmonary Disease; copd (chronic obstructive pulmonary disease); Middle Aged; Polymorphism, Single Nucleotide; polymorphism; 3. Good health; risk.; Diseases of the respiratory system; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; Asian People; Gene Frequency; Case-Control Studies; Humans; Genetic Predisposition to Disease; Original Research; Aged; Smad4 Protein

COPD is a respiratory disease caused by combination of genetic and environmental factors. Polymorphism, as factor, can affect the susceptibility COPD. In this study, we assessed relationship between polymorphisms three genes risk in Chinese Han population.A total 376 patients diagnosed with 284 control subjects were enrolled study. Multivariate logistic regression analysis was used to analyze association (SMAD4 rs10502913, IL-4 rs2070874, HSPA1L rs2227956) susceptibility.The SMAD4 rs10502913 GG AG genotype significantly increased (adjusted OR = 2.235, 95% CI 1.198-4.104; adjusted 2.218, 1.204-4.151, respectively) compared AA genotype. stratification analyses, aged 60 over 2.519, 1.266-5.015) smoking history less than 30 years (p=0.009; 3.751; 1.398-10.062). This more pronounced group GOLD I II 3.628, 1.022-12.885; 2.394, 1.004-5.710, respectively). addition, associated an 2.599, 1.304-5.176) smokers (p=0.021; 2.269; 1.132-4.548). obvious III (p=0.047; 2.532; 1.012-6.336).Our present study indicated that are population. Further validation studies large-scale populations needed confirm our findings.