Changes in plasma levels of B-type natriuretic peptide with acute exacerbations of chronic obstructive pulmonary disease

• DOI: 10.2147/copd.s55143
• Publication Date: 2014-02-07T01:55:16Z
• Authors: Koichi Nishimura; Takashi Nishimura; Katsuya Onishi; Toru Oga; Yoshinori Hasegawa; Paul Jones
• Keywords: Interquartile range; Brain natriuretic peptide; Obstructive lung disease

Changes in plasma levels of B-type natriuretic peptide with acute exacerbations chronic obstructive pulmonary disease Koichi Nishimura,1 Takashi Nishimura,2 Katsuya Onishi,3 Toru Oga,4 Yoshinori Hasegawa,5 Paul W Jones61Department Pulmonary Medicine, National Center for Geriatrics and Gerontology, Obu, Japan; 2Kyoto-Katsura Hospital, Kyoto, 3Onishi Heart Clinic, Tsu, 4Department Respiratory Care Sleep Control Graduate School Kyoto University, 5Division Department Nagoya University Nagoya, Aichi, 6Division Clinical Science, St George's Hospital Medical School, London, EnglandBackground: Elevated (BNP) their association heart failure have been reported subjects (AECOPD).Purpose: To examine compare BNP diastolic systolic dysfunction AECOPD stable (COPD).Methods: In all, 87 unselected consecutive hospitalizations due to 61 a total 190 COPD were recruited. Plasma compared cross-sectionally longitudinally. Transthoracic echocardiographic examinations also performed the hospitalized subjects.Results: subjects, median level (interquartile range) was 55.4 (26.9–129.3) pg/mL higher than that patients COPD: 18.3 (10.0–45.3) Global Initiative Chronic Obstructive Lung Disease grade I; 25.8 (11.0–53.7) II; 22.1 (9.1–52.6) III; 17.2 (9.6–22.9) IV, all P