Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure

• DOI: 10.2147/dmso.s37830
• Publication Date: 2013-02-18T15:38:55Z
• Authors: Evgenya Uchasova ...; Olga Gruzdeva; Yulia Dyleva; Ekaterina Belik; Vasiliy Kashtalap; Olga Barbarash
• Keywords: Dyslipidemia; Killip class

Background: The most common cause of myocardial infarction (MI) is stenotic atherosclerotic lesions in subepicardial coronary arteries. Artery disease progression induces clinical signs and symptoms, among which MI the leader mortality morbidity. Recent studies have been trying to find new biochemical markers that could predict evolution complications; those markers, free fatty acids (FFA) oxidative modification low-density lipoproteins (oxidized LDL) a special place. Materials methods: Seventy-nine ST-elevation patients were enrolled. first group included without acute heart failure (Killip class I) while with Killip classes II–IV made up second group. Thirty-three individuals no cardiovascular controls. lipid profile, serum oxidized LDL, their antibodies, C-peptide insulin measured at days 1 12. level resistance was assessed quantitative sensitivity check index (QUICKI). Results: had atherogenic dyslipidemia; however, pronounced prolonged increase FFA, antibodies. Additionally, positive correlations between FFA levels creatine kinase activity (12 days, R = 0.301; P 0.001) negative QUICKI (R –0.46; 0.0013 –0.5; 0.01) observed both groups. Conclusion: development complications accompanied by significant levels, not only demonstrate injury, but also take part resistance. Measuring can great prognostic potential for risk stratification recurrent events choice treatment strategy. Keywords: infarction, acids,