Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

• DOI: 10.2147/ijn.s127715
• Publication Date: 2017-02-12T23:04:22Z
• Authors: Yang Zhang; Ruo-jia Liang; Jiao-jiao Xu; Li-feng Shen; Jian-qing Gao; Xu-ping Wang; Na-ni Wang; Dan Shou; Ying Hu
• Keywords: Protein Adsorption

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system Yang Zhang,1,* Ruo-jia Liang,2,* Jiao-jiao Xu,3 Li-feng Shen,1 Jian-qing Gao,4 Xu-ping Wang,1 Na-ni Dan Shou,1 Ying Hu3 1Department Medicine, Zhejiang Academy Traditional Chinese 2Department Gynaecology, Provincial Hospital Hangzhou, 3Zhejiang Pharmaceutical College, Ningbo, 4College Sciences, University, People’s Republic China *These authors contributed equally to this work Abstract: Surgery and the local placement an antibiotic are predominant therapies to treat chronic osteomyelitis. Vancomycin-loaded N-trimethyl chitosan nanoparticles (VCM/TMC NPs) as a potential have high intracellular penetration effective antibacterial activity. This study investigated effects biocompatible material, (PTMC), increase sustained effectiveness its application in delivery. VCM/TMC NP-PTMC was characterized using scanning electron microscopy Fourier transform infrared spectroscopy determine morphology, stability chemical interaction polymer. Further, biodegradation, activity, protein adsorption, cell proliferation release characteristics were evaluated. In addition, Staphylococcus aureus-induced osteomyelitis rabbit model used investigate bone repair capability NP-PTMC. The results showed that composite beads NPs followed slow pattern had excellent higher adsorption rate than VCM-PTMC vitro. Furthermore, inhibits bacteria promotes vivo. Thus, might be beneficial periodontal management reduce bacterial load at infection site promote repair. Keywords: vancomycin-loaded nanoparticles, carbonate), release, effect,