SL2B aptamer and folic acid dual-targeting DNA nanostructures for synergic biological effect with chemotherapy to combat colorectal cancer

• DOI: 10.2147/ijn.s132929
• Publication Date: 2017-04-04T00:18:10Z
• Authors: Pengchao Sun; Nan Zhang; Yafang Tang; Yanan Yang; Xiao Chu; Yongxing Zhao
• Keywords: Aptamer

Abstract: DNA nanostructures prepared by self-assembly possess good stability, high biocompatibility, and low immunogenicity as drug delivery vehicles. In this work, tetrahedron (TD) was constructed modified with SL2B aptamer (S) folic acid (F). TD possessed a small diameter (~6 nm) entered into the nucleus quickly. can inhibit cancer cell growth disturbing vascular endothelial factor/Notch signaling pathways. To explore effect of number on colorectal inhibition, multimers (dimer, trimer, tetramer) were functionalization different numbers SL2B. One per most efficient anticancer strategy showed significantly better efficacy than SL2B, probably due to enhanced stability TD. Doxorubicin (DOX) is potent agent that intercalate double strands. Results could facilitate DOX entrance intracellular further F. DOX-intercalated two F S ( [email protected] ) cause sufficient HT-29 inhibition at much lower concentration. sum, exhibited synergic biological chemotherapy be promising for treating cancer. Keywords: aptamer, tetrahedron, chemotherapy, cancer, doxorubicin, VEGF/Notch,