Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment

• DOI: 10.2147/ijn.s150610
• Publication Date: 2017-12-27T23:06:56Z
• Authors: Dandan Wang; Xiaowei Xu; Kai Zhang; Bin Sun; Lu Wang; Lin Meng; Qilin Liu; Changyu Zheng; Bai Yang; Hongchen Sun
• Keywords: Doxorubicin Hydrochloride

Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment Dandan Wang,1,* Xiaowei Xu,2,* Kai Zhang,3 Bin Sun,4 Lu Wang,1 Lin Meng,1 Qilin Liu,4 Changyu Zheng,5 Bai Yang,3 Hongchen Sun1,3,6 1Department Pathology, School Hospital Stomatology, Jilin University, Changchun, People’s Republic China; 2Department Periodontology, 3State Key Laboratory Supramolecular Structure Materials, College Chemistry, 4Department Oral Maxilloficial Syrgery, 5Molecular Physiology Therapeutics Branch, National Institute Dental Craniofacial Research, Institutes Health, Bethesda, MD, USA; 6Key Science Technology for Stomatology Nanoengineering, The Education Department Province, China *These authors contributed equally this work Abstract: cancer is a type head neck that the seventh most frequent ninth cause death globally. About 90% cell type. Surgery radiation with without chemotherapy are major treatments cancer. Better advanced still needed. Multidrug resistance plays an important role in failure chemotherapy. In study, we tried fabricate novel nanoparticle could carry both block MDR1 expression (DOX), drug, into cells order directly kill little or no effect multidrug resistance. Results showed nanoparticles (MSNP) can be modified cationic polymerpolyethylenimine (PEI) obtain positive charges on surface, which enable MSNP DOX. transfection efficiency assays demonstrated MSNP-PEI-DOX/MDR1-siRNA was efficiently transfected KBV vitro. effectively decrease gene (~70% increase after 72 hours posttreatment) induce apoptosis (24.27% 48 Importantly, dramatically reduced tumor size (81.64% 28 days slowed down growth rate compared control group vivo (P