<p>Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy</p>

• DOI: 10.2147/ijn.s174962
• Publication Date: 2019-02-25T23:44:33Z
• Authors: Pei-Chi Lee; Bo-Shen Zan; Li-Ting Chen; Tze-Wen Chung
• Keywords: PLGA; Targeted drug delivery

Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which tissue damage.In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant antioxidant properties in therapy.Both heparin glutathione entrapped on PLGA-stearylamine by layer-by-layer interactions.The drug release rate is successfully controlled with only 10.3% released after 96 hours. An H2O2-responsive platform also developed combining silk fibroin horse peroxidase detect delivery system. Besides, hyaluronic acid was decorated surface target human bone marrow mesenchymal stem cells (hBMSCs) cell therapy. The results an vitro study indicate that could be taken up hBMSCs within 2 hours exocytosis occurred 6 cellular uptake.We propose multifunctional formed herein can effectively delivered site I/R via hBMSC homing effect. proposed approach potentially treat diseases, providing a wide range drugs.