Combined ROS Sensitive PEG-PPS-PEG with Peptide Agonist for Effective Target Therapy in Mouse Model

• DOI: 10.2147/ijn.s471036
• Publication Date: 2024-09-05T09:05:22Z
• Authors: Pingping Xiang; Qi Liu; Wangwei Jing; Yaping Wang; Hong Yu
• Keywords: reactive oxygen species; Male; Medicine (General); Myocardial Infarction; Apoptosis; Sulfides; targeted therapy; Growth Hormone-Releasing Hormone; Polyethylene Glycols; Mice, Inbred C57BL; Mice; Disease Models, Animal; myocardial infarction; R5-920; growth hormone-releasing hormone; Animals; Myocytes, Cardiac; Reactive Oxygen Species; Peptides; Original Research

Growth hormone-releasing hormone (GHRH) agonist, a 29-amino acid peptide, shows significant potential in treating myocardial infarction (MI) by aiding the repair of injured heart tissue. The challenge lies effective on-site delivery GHRH agonist. This study explores use targetable system employing ROS-responsive PEG-PPS-PEG polymers to encapsulate and deliver agonist MR409 for enhanced therapeutic efficacy.