Multiomic Profiling and Neuroprotective Bioactivity of Salvia Hairy Root-Derived Extracellular Vesicles in a Cellular Model of Parkinson’s Disease

• DOI: 10.2147/ijn.s479959
• Publication Date: 2024-09-11T08:37:05Z
• Authors: Vincenzo Vestuto; Marisa Conte; Mariapia Vietri; Francesca Mensitieri; Valentina Santoro; Anna Di Muro; Mariaevelina Alfieri; Maria Moros; Maria Rosaria Mir...; Chiara Amante; Matteo Delli Carri; Pietro Campiglia; Fabrizio Dal Piaz; Pasquale Del Gaudio; Nunziatina De Tom...; Antonietta Leone; Ornella Moltedo; Giacomo Pepe; Elisa Cappetta; Alfredo Ambrosone
• Keywords: Extracellular Vesicles; Profiling (computer programming); Salvia

Extracellular vesicles (EVs) are promising tools for nanomedicine and nanobiotechnology. The purification of mammalian-derived EVs involves intensive processes, their therapeutic application raises multiple safety regulatory issues. Plants have the potential to serve as nonconventional sources therapeutically relevant EVs. In this context, we recently identified hairy roots (HRs) medicinal plants a novel biotechnological platform produce human health.