Mechanism of Antioxidant Activity of Selenium Nanoparticles Obtained by Green and Chemical Synthesis

• DOI: 10.2147/ijn.s507712
• Publication Date: 2025-03-06T02:20:11Z
• Authors: Anna Grudniak; Julia Folcik; Jakub Szmytke; Aleksandra Sentko...
• Keywords: Environmentally Friendly

Background: Selenium nanoparticles (SeNPs) show high therapeutic potential. SeNPs obtained by green synthesis methods, using commonly available plants, are an attractive alternative to classical, chemical methods. The process uses environmentally friendly reagents, which offer eco-friendly advantage. Clarifying their mechanism of action is key safe use. Methods: study used extracts sage, hops, blackberry, raspberry, and lemon balm, without the use additional stabilizers, chemically with ascorbic acid gallic acid, stabilized polyvinyl alcohol. was carried out on a model strain Escherichia coli. In study, activities enzymes catalase (CAT), superoxide dismutase (SOD), response bacterial cells osmotic shock were determined. Results: One mechanisms related formation ROS in cells. tested showed strong inhibition CAT, enzyme crucial for that involved removal hydrogen peroxide. also had effect reducing activity reactive oxygen species from Green shown be cellular shock, confirming pleiotropic Conclusion: NPs synthesized via methods exhibit antibacterial against E. employs offering pro-ecological Notably, these strongly post-reaction mixture, eliminating need toxic stabilizers. Their antimicrobial involves generation, (CAT) inhibition, reduced SOD activity, affecting defense disrupting shock. Keywords: selenium nanoparticles, catalase, dismutase,