Dynamic Lymphocyte Changes Following Transarterial Radioembolization: Association with Normal Liver Dose and Effect on Overall Survival

• DOI: 10.2147/jhc.s350219
• Publication Date: 2022-02-03T13:30:08Z
• Authors: Shamar Young; Ranjan Ragulojan; Ting Chen; Joshua Owen; Donna D'Souza; Tina Sanghvi; Jafar Golzarian; Siobhan Flanagan
• Keywords: Univariate analysis

To evaluate the dynamic changes of lymphocytes following transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) and their relationship to normal liver dose (NLD).A total 93 patients who underwent 102 treatments were retrospectively reviewed. Absolute lymphocyte counts pretreatment at 1, 3, 6, 12 months evaluated. Kaplan-Meier, Spearman correlation, receiver operating characteristic (ROC) curve, area under curve (AUC) analyses performed.The mean absolute count baseline was 1.25 ± 0.79 103/µL which significantly greater than 1 (0.71 0.47 103/µL, p<0.0001), 3 (0.79 0.77 p=0.0003), 6 (0.81 0.44 p=0.0001) months, but not different (0.92 0.8 p=0.12) post treatment. There a modest negative correlation between NLD month (rho= -0.216, p=0.03), strengthened treatment -0.342, p=0.008). AUC ROC analysis ≤1 or >1 0.625, 0.676, 0.560, 0.794, respectively. Univariate overall survival when separating by demonstrated significant difference (HR: 0.56, 95% CI: 0.33-0.95, 0.41, 0.18-0.94, p=0.035) 0.36, 0.17-0.77, p=0.008) treatment, months.NLD may correlate with depression lymphopenia portend worse in setting.