IL-6 Released from Hepatic Stellate Cells Promotes Glycolysis and Migration of HCC Through the JAK1/vWF/TGFB1 Axis

• DOI: 10.2147/jhc.s464880
• Publication Date: 2024-07-04T12:51:11Z
• Authors: Yifei Zhu; Jiayi Gu; Yuxin Lu; Qianying Tao; Xinliang Cao; Yanqing Zhu; Mu-qing Yang; Xin Liang
• Keywords: Hepatic stellate cell; Hepatocellular cancer

Purpose: The crosstalk between hepatocellular carcinoma (HCC) cells and hepatic stellate (HSCs) is one of the important mechanisms liver cancer metastasis. relationship metastasis glycolysis has been extensively studied recently. However, role von Willebrand factor (vWF) mediated mechanism in currently unknown. Methods: Western blot was used to verify expression vWF HCC cells. PAS staining, glycogen L-lactate content assays were reflect cellular levels. ability cell migration explored by Wound-healing Transwell assays. Besides, effect on progression vivo also using subcutaneous xenograft model. Results: derived from promoted tumor mediating glycolysis. participated HSCs. activated HSCs through vWF-mediated TGFB1 secretion, upregulated IL-6 secretion feedback. Further, vitro experiments confirmed importance JAK1/vWF/TGFB1 axis regulating HSCs-derived growth. Conclusion: In summary, this article demonstrated that released enhanced activating which may be a potential target for inhibiting Keywords: glycolysis, crosstalk, vWF,