The treatment of nonunions with application of BMP-7 increases the expression pattern for angiogenic and inflammable cytokines: a matched pair analysis

• DOI: 10.2147/jir.s110621
• Publication Date: 2016-09-22T21:37:11Z
• Authors: Patrick Haubruck; Andreas Kammerer; Sebastian Korff; Philipp Apitz; Kai Xiao; Axel Büchler; Bahram Biglari; Gerald Zimmermann; Volker Daniel; Gerhard Schmidmaier; Arash Moghaddam
• Keywords: Expression (computer science)

Abstract: The local application of bone morphogenetic protein-7 (BMP-7) in combination with the transplantation autologous graft improves outcome nonunion treatment; however, specific reasons remain unclear. In this study, we sought to determine if BMP-7 contributes improved regeneration therapy by modulation angiogenic and inflammable cytokine expression patterns early inflammation response. Therefore, utilized analysis serological patterns. As a matched pair analysis, best-fitting patients who were treated (G1, n=10) compared additional (G2, n=10). changes monitored correlated clinical data healing. Significant differences angiogenesis potential (vascular endothelial growth factor [VEGF] serum levels) could be found first days after surgery ( P <0.05). Furthermore, increase absolute amount VEGF levels group considerably higher than control during 2 weeks surgery. pattern cytokines showed noticeable time point significant elevated levels, particular, an earlier peak G2. interleukin-6 was significantly within week only, comparing G2 G1 Our findings indicate that induces more intense via direct postulated indirect pathway, thereby providing favorable environment for Moreover, leads known proinflammatory cytokines. results study show costimulatory effect on both may serve as possible stimulus regeneration. Keywords: regeneration, angiogenesis, VEGF, IL-6, inflammation,