Altered T-Cell Subsets are Associated with Dysregulated Cytokine Secretion of CD4+ T Cells During HIV Infection

• DOI: 10.2147/jir.s333902
• Publication Date: 2021-10-08T09:40:56Z
• Authors: Di Wang; Yu Jiang; Yangzi Song; Yongqin Zeng; Cuilin Li; Xinyue Wang; Ying Liu; Jiang Xiao; Yaxian Kong; Hongxin Zhao
• Keywords: hiv infection; t-cell subsets; 0301 basic medicine; RM1-950; t-cell dysfunction; cytokines; 3. Good health; 03 medical and health sciences; inflammatory responses; Pathology; RB1-214; Therapeutics. Pharmacology; Journal of Inflammation Research; Original Research

CD4+ T cells play a critical role in the regulation of immunopathogenesis HIV infection. Previous studies have shown contradictory results T-cell responses people living with (PLHIV).A cross-sectional study was performed on 40 healthy controls, 134 ART-naïve PLHIV, and 34 individuals who experienced 3-year ART low baseline CD4 count from 4 August 2016 to 23 January 2019. We determined frequencies subsets described cytokine secretion pattern total these individuals.We found that PLHIV displayed enhanced pro-inflammation cytokines polyfunctionality due disease progression (r = -0.282, P 0.0035 for IFN-γ; r -0.412, 0.0002 TNF-α; -0.243, < 0.0001 GM-CSF; -0.252, 0.0093 IFN-γ+ TNF-α+ cells). However, altered subsets, as presented by loss naïve expansion memory/effector population were associated discordant cells. As major cytokine-producing effector/memory showed impaired production (P 0.05). further demonstrated treatment could improve counts increasing pool but not restore 0.05).These data identified capacity progression, pseudo-elevation This collectively suggested importance therapies can preserve and/or enhance function strategies remission.