C-Reactive Protein-Albumin Ratio (CAR): A More Promising Inflammation-Based Prognostic Marker for Patients Undergoing Curative Hepatectomy for Hepatocellular Carcinoma

• DOI: 10.2147/jir.s441623
• Publication Date: 2024-02-12T03:15:05Z
• Authors: Rong-Yun Mai; Ting-Li Lu; Ri-Jin Lu; Can Zeng; Fang Lian; Le-Qun Li; Guo-Bin Wu; Jia-Zhou Ye
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Journal of Inflammation Research; Original Research

Background: Systemic inflammatory response is a hallmark of cancer and plays significant role in the development progression various malignant tumors. This research aimed to estimate prognostic function C-reactive protein-albumin ratio (CAR) patients undergoing hepatectomy for hepatocellular carcinoma (HCC) compare it with other inflammation-based scores, including neutrophil-lymphocyte ratio, platelet-lymphocyte monocyte-lymphocyte systemic immune inflammation index, Glasgow score, modified score. Methods: Retrospective analysis was conducted on data from 1039 HCC cases who underwent curative liver resection. The performance CAR compared scores using area under time-dependent receiver operating characteristic (t-ROC) curve. Multivariable Cox regression analyses were performed confirm independent predictors disease-free survival (DFS) overall (OS). Results: t-ROC curve evaluation DFS OS significantly greater than that alpha-fetoprotein (AFP). Patients stratified based optimal cut-off value CAR, revealed both remarkably worse high-CAR set low-CAR set. demonstrated an parameters assessing OS. Regardless AFP levels, all subsequently divided into different subgroups risk stratification. Similar results observed when applying stratification scoring systems. also showed good clinical applicability features. Conclusion: more effective marker predicting as well among after hepatectomy. Keywords: carcinoma, hepatectomy, response, marker, protein albumin