The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis

• DOI: 10.2147/jpr.s147640
• Publication Date: 2017-10-10T19:08:51Z
• Authors: Nidhi Sofat; Abiola Harrison; Mark Russell; Salma Ayis; Patrick D Kiely; Emma H Baker; Thomas Barrick; Franklyn Howe
• Keywords: Pregabalin; Clinical endpoint

Osteoarthritis (OA) is the most prevalent arthritis worldwide and characterized by chronic pain impaired physical function. We hypothesized that heightened in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 years, a Numerical Rating Scale (NRS) for of at least 5. Participants were to one following three groups: duloxetine, pregabalin, placebo. The primary endpoint was NRS score, secondary endpoints included Australian Canadian Hand Index (AUSCAN) pain, stiffness, function scores quantitative sensory testing pressure algometry. After 13 weeks, compared placebo, ANOVA found significant differences between groups (P=0.0078). intention-to-treat analysis, pregabalin group showed improvement (P=0.023), AUSCAN (P=0.008), (P=0.009), but no difference placebo (P>0.05) observed. per protocol (P<0.0001) (P=0.029) conclude centrally acting analgesics improve outcomes people arthritis, offering new treatment paradigms pain.