Cortical Sulcal Abnormalities Revealed by Sulcal Morphometry in Patients with Chronic and Episodic Migraine

• DOI: 10.2147/jpr.s447148
• Publication Date: 2024-02-01T04:21:21Z
• Authors: Shanyu Liu; Xiaolin Hou; Min Shi; Yuling Shen; Zhaoying Li; Zhenzhu Hu; Dongdong Yang
• Keywords: Sulcus; Central sulcus

Purpose: Previous studies have reported mixed results regarding the importance of cortical abnormalities in patients with migraines. However, sulci, as a component cerebral cortex, not been specifically investigated migraine patients. Therefore, we aim to evaluate alterations sulcal morphology among chronic (CM), episodic (EM), and healthy controls (HCs). Patients Methods: In this cross-sectional study, structural magnetic resonance images were acquired from 35 CM, EM, HCs. Cortical sulci identified reconstructed using BrainVisa 5.0.4 software. We focused on regions involved pain processing which abnormal structure previous neuroimaging studies. Morphometric analysis was performed calculate parameters including mean depth, thickness, opening width. Partial correlation analyses clinical characteristics for EM combined (CM + EM) groups. Results: comparison HCs, both CM groups showed increased width bilateral insula. HC groups, thickness superior postcentral sulcus, median frontal sulcus left parietal well depth anterior callosomarginal fissure decreased sulcus. Migraine frequency disease duration correlated Conclusion: Abnormal morphometry primarily affected areas associated migraine, exhibiting more extensive related sensory affective processing. These changes may contribute understanding pathology CM. Keywords: morphometry, width,