Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report

• DOI: 10.2147/nss.s286358
• Publication Date: 2020-12-30T22:12:36Z
• Authors: Gaia Pellitteri; Pierluigi Dolso; Mariarosaria Valente; Gian Luigi Gigli
• Keywords: Psychiatry; Neurophysiology and neuropsychology; cataplexy; QP351-495; nt1; RC435-571; Case Report; 3. Good health; NT1; cataplexy; narcolepsy treatment; sexual dysfunction; 03 medical and health sciences; 0302 clinical medicine; sexual dysfunction; Nature and Science of Sleep; narcolepsy treatment.

Abstract: We describe a case of young male patient with narcolepsy type 1 (NT1), who developed generalized cataplexy attacks during sexual intercourses, on which we have obtained satisfactory control pitolisant. Orgasmolepsy is an uncommon feature NT1 that has been poorly described in the literature. The prevalence this condition unclear, as it reasonably underreported by patients for embarrassment and not well investigated physicians. Pitolisant novel treatment narcolepsy, effective excessive daytime sleepiness modulating histaminergic system. Real-world data collection pitolisant efficacy safety still ongoing. However, effectiveness orgasmolepsy no precedent other disturbances should be actively searched narcoleptic and, if present, may guide clinicians to prefer or sodium oxybate, avoiding antidepressants their possible side effects. Keywords: NT1, cataplexy, dysfunction,