Association of Craniofacial and Upper Airway Morphology with Cardiovascular Risk in Adults with OSA

• DOI: 10.2147/nss.s332117
• Publication Date: 2021-10-01T05:11:48Z
• Authors: Li Zhang; Xiaolei Zhang; Yi Ming Li; Bo Yun Xiang; Teng Han; Yan Wang; Chen Wang
• Keywords: Psychiatry; Neurophysiology and neuropsychology; QP351-495; n-terminal pro b-type natriuretic peptide; RC435-571; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; framingham cardiovascular risk; Nature and Science of Sleep; craniofacial and upper airway morphology; obstructive sleep apnea; Original Research

Background and Objective: Clinical population-based studies have demonstrated a strong association between obstructive sleep apnea (OSA) cardiovascular disease (CVD). Anatomical abnormalities of the craniofacial region upper airway are important risk factors for OSA. The objective this study was to investigate morphology with CVD biomarkers. Methods: One hundred sixty-nine male patients OSA underwent in-laboratory polysomnography (PSG) computed tomography (CT) scanning. Ten-year Framingham score (FRS) calculated categorized into low- moderate-to-high-risk groups. N-terminal pro B-type natriuretic peptide (NT-proBNP) measured as biomarker increased myocardial wall stress. Results: Compared low-risk group, total time (TST), proportion N3 (N3%) mean oxygen saturation (SpO 2 mean) were lower, while arousal index non-rapid eye movement (NREM) sleep, (AI) NREM hypopnea (AHI) desaturation (ODI) percentage spent oxyhemoglobin below 90% (TST90) higher in moderate-to-high group. corrected length (UAL), ANB angle gonion-gnathion-hyoid larger subjects group than those In multiple regression analysis, TST, AI adjusted UAL independently associated risk. Plasma NT-proBNP levels moderate- high-risk among PSG CT scan parameters, only SPO marginally (r=0.183, P=0.054). Conclusion: Craniofacial features may contain valid cues about risk, duration, event type occurrence phase be closely related Keywords: morphology, apnea,