Cytokine biomarkers in tear film for primary open-angle glaucoma

• DOI: 10.2147/opth.s125364
• Publication Date: 2017-02-22T17:50:31Z
• Authors: Divakar Gupta; Joanne C. Wen; Janet L Huebner; Sandra Stinnett; Virginia B Kraus; Henry C Tseng; Molly Walsh
• Keywords: Proinflammatory cytokine

Purpose: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). Methods: Patients without POAG and eye drop-naïve patients with newly diagnosed were recruited from an academic hospital-based practice. Tear films obtained analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay proinflammatory (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, TNFα). Results: Mean concentrations lower in group 8 10 tested. IL-12p70 (3.94±2.19 pg/mL control vs 2.31±1.156 POAG; P =0.035) was significantly POAG. Conclusion: Proinflammatory patients. cytokine profiles may be used Keywords: glaucoma, biomarkers, film, cytokines, diagnosis, limit detection