LincRNA-p21 inhibits invasion and metastasis of hepatocellular carcinoma through miR-9/E-cadherin cascade signaling pathway molecular mechanism

• DOI: 10.2147/ott.s134910
• Publication Date: 2017-07-02T22:10:16Z
• Authors: Gangqiang Ding; Zhen Peng; Jia Shang; Yi Kang; Huibin Ning; Chongshan Mao
• Keywords: 0303 health sciences; 03 medical and health sciences; OncoTargets and Therapy; Original Research; 3. Good health

Abstract: In the previous study, it was found that long intergenic noncoding RNA-p21 (lincRNA-p21) downregulated in hepatocellular carcinoma (HCC) and lincRNA-p21 overexpression inhibited tumor invasion through inducing epithelial–mesenchymal transition. However, underlying mechanism not fully elaborated. this expression measured 12 paired HCC nontumor adjacent normal tissues by ­quantitative real-time polymerase chain reaction. The effects of on cells were studied using lentivirus expressing vector vitro. association between level miR-9 tested with Spearman rank correlation. inhibitor Luciferase assay used to validate target miR-9. results showed human cell lines. LincRNA-p21 significantly migration Besides, negatively regulated level, upregulated cells. MiR-9 knockdown Finally, luciferase E-cadherin a direct be Altogether, suggested inhibits regulating miR-9-mediated cascade signaling pathway. Keywords: carcinoma, lincRNA-p21, miR-9, E-cadherin, transition