Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways

• DOI: 10.2147/ott.s149708
• Publication Date: 2017-11-16T00:31:16Z
• Authors: Jun Zhao; Jiabin Zhu; Xiaoshu Lv; Jinshan Xing; Shuang Liu; Chen Chen; Yinghui Xu
• Keywords: OncoTargets and Therapy; Original Research; 3. Good health

Glioblastoma (GBM) is a highly invasive and challenging primary tumor of the central nervous system (CNS), currently available treatments provide limited benefits to patients with this disease.Therefore, development novel therapeutic targets effective treatment strategies essential.Nimustine hydrochloride (ACNU) widely used as standard chemotherapeutic agent frequently administered together other agents in clinical studies.Curcumin, natural polyphenolic compound, could potentially be combined chemotherapeutics for cancer treatment; however, there are no reports studies where ACNU curcumin were GBM treatment, mechanisms underlying their activity remain poorly understood.In present study, we investigated effects on cells found that it significantly enhanced inhibition cell proliferation, colony formation, migration, invasion.In addition, cotreatment increased ACNU-induced apoptosis through enhancing release cytochrome c from mitochondrial intermembrane space into cytosol.Further, acted synergistically antitumor by targeting N-cadherin/MMP2/9, PI3K/AKT, NF-κB/COX-2 signaling.These results indicate can enhance anti-proliferation, anti-migration, proapoptotic activities against GBM, strong evidence has potential an option GBM.