Associations between the <em>NUDT15&nbsp;</em>R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis

• DOI: 10.2147/ott.s177007
• Publication Date: 2018-11-22T18:20:55Z
• Authors: Yulan Liu; Yang Meng; Lu Wang; Zhou Liu; Jiao Li; Weiguo Dong
• Keywords: Leukopenia; Thiopurine methyltransferase

Background and aim: Despite several studies being conducted to examine the associations between NUDT15 R139C polymorphism thiopurine-induced leukopenia in Asian population, results remain inconsistent. This meta-analysis determined risk of conferred by polymorphism. Materials methods: All eligible published English up May 2018 were identified searching PubMed, Web Science, Embase, Cochrane Library. Pooled OR 95% CI calculated using fixed- or random-effect model. Results: In all, total 14 containing 918 patients 2,341 controls included; these, 8 concerned inflammatory bowel disease (IBD) 4 acute lymphoblastic leukemia (ALL). Overall, indicated that was associated with induced thiopurines (OR =9.04, 6.05–13.50, P <0.001 for dominant model; =24.26, 11.38–51.71, recessive =7.60, 4.97–11.61, CT vs TT =38.47, 17.78–83.24, CC model). subgroup analyses, significant found among IBD =7.57, 5.16–11.12, model), ALL =13.13, 3.43–50.23 other diseases =31.22, 1.20–814.07, =0.04 addition, variant strongly early (<8 weeks) =15.53, 7.91–30.50, model) late (≥8 =2.92, 2.01–4.24, Moreover, these findings sufficiently robust when without Hardy–Weinberg equilibrium test excluded. Conclusion: verified strong association (both leukopenia) an population IBD, ALL, diseases. genotyping should be prioritized predict Asians. Keywords: R139C, leukopenia, thiopurine, polymorphism,