<p>MiR-200a-3p promoted the malignant behaviors of ovarian cancer cells through regulating PCDH9</p>

• DOI: 10.2147/ott.s220339
• Publication Date: 2019-10-08T00:17:25Z
• Authors: Can Shi; Yijun Yang; Lei Zhang; Juanpeng Yu; Shanshan Qin; Hongge Xu; Yingchun Gao
• Keywords: 0301 basic medicine; 03 medical and health sciences; OncoTargets and Therapy; Original Research; 3. Good health

Background: Increasing evidence has revealed that the aberrant expression of microRNAs (miRNAs) plays vital roles in development and progression ovarian cancer. MiR-200a-3p was found to act as an oncogene a variety cancers, however, function miR-200a-3p cancer not been characterized. Materials methods: The tissues cell lines detected by RT-qPCR. influence on growth cells determined with Cell Counting Kit-8 assay, colony formation invasion assay. binding 3ʹ-untranslated region (UTR) PDCH9 luciferase reporter PCDH9 investigated RT-qPCR Western blot analysis. Results: up-regulated lines. Highly expressed significantly associated tumor size, metastasis TNM stage. Overexpression markedly promoted proliferation, cells. Functional study uncovered bound decreased negatively correlated PCDH9. Restored inhibited promoting effect proliferation Conclusion: Our results suggested potential oncogenic via modulating Keywords: miR-200a-3p, cancer,