<p>Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer</p>

• DOI: 10.2147/ott.s265324
• Publication Date: 2020-12-07T20:26:35Z
• Authors: Dandan Zheng; Chengwei Jiang; Ning Yan; Yayun Miao; Keren Wang; Ge Gao; Yan Jiao; Xiangkai Zhang; Miao He; Zhaoying Yang
• Keywords: 0303 health sciences; 03 medical and health sciences; OncoTargets and Therapy; Original Research; 3. Good health

Wntless (Wls) is an essential protein that necessary for the secretion of Wnt proteins. While numerous researches have demonstrated aberrations in Wnt/β-catenin expression lead to tumorigenesis and progression many cancer types, effects Wls breast (BC) are less studied.The mRNA BC cell lines were detected by RT-qPCR Western blot; patient samples was immunohistochemistry (IHC). The associations between clinicopathological factors as well survival time, including overall (OS) disease-free (DFS) analyzed. Bioinformatics analysis used reveal correlation genes associated or pathways.Wls overexpressed tissues. level significantly correlated with tumor size, estrogen receptor (ER), progesterone (PR), Ki-67, molecular classification, follow-up status. Spearman showed negatively ER PR, which confirmed bioinformatics level. However, there positive relationships MBNG (modified Black's nuclear grade), follow-up, vital Univariate multivariate independent prognostic factor OS DFS patients. Moreover, a significant indicator hormone receptor-positive (HR+) subgroup. GSEA androgen response, epithelial-mesenchymal transition pathways, up-regulated high-expression group.Overexpression marker worse prognosis might play crucial role HR+