Serum Osteopontin, KL-6, and Syndecan-4 as Potential Biomarkers in the Diagnosis of Coal Workers’ Pneumoconiosis: A Case–Control Study

• DOI: 10.2147/pgpm.s409644
• Publication Date: 2023-06-01T04:20:13Z
• Authors: Zhifei Hou; Xinran Zhang; Yong Gao; Jing Geng; Yu Jiang; Huaping Dai; Chen Wang
• Keywords: Osteopontin; Pneumoconiosis; Syndecan 1

Background: Coal worker's pneumoconiosis (CWP) is a chronic occupational disease mainly caused by coal dust inhalation in miners. This study aimed to investigate the clinical value of Osteopontin (OPN), KL-6, Syndecan-4 and Gremlin-1 as serum biomarkers CWP. Patients Methods: We integrated reported lung tissues transcriptome data patients with silica-exposed alveolar macrophage microarray identify four CWP-associated biomarkers. The concentrations Osteopontin, Krebs von den Lungen-6 (KL-6), were measured 100 healthy controls (HCs), dust-exposed workers (DEWs) 200 Receiver operating characteristic (ROC) curve analysis was used determine sensitivity, specificity, cut-off area under (AUC) Results: pulmonary function parameters decreased sequentially, OPN, increased sequentially among HC, DEW CWP groups. Among all participants, multivariable revealed that these negatively correlated (all p < 0.05). Compared HCs, higher had risk for combination can improve diagnostic sensitivity specificity differentiated from HCs or DEWs. Conclusion: KL-6 are novel be auxiliary diagnosis. three values Keywords: workers' pneumoconiosis, biomarker, osteopontin, Lungen-6, Syndecan-4,