Impact of recipient-related factors on structural dysfunction of xenoaortic bioprosthetic heart valves

• DOI: 10.2147/ppa.s76001
• Publication Date: 2015-03-09T22:50:20Z
• Authors: Evgenya Uchasova; Olga Barbarash; Natalya Rutkovskaya; Oksana Hryachkova; Olga Gruzdeva; Anastasia Ponasenko; Natalya Kondyukova; Yuri Odarenko; Leonid Barbarash
• Keywords: Interquartile range; Proinflammatory cytokine; Osteopontin

To analyze the influence of recipient-related metabolic factors on rate structural dysfunction caused by calcification xenoaortic bioprostheses.We retrospectively analyzed clinical status, calcium-phosphorus metabolism, and nonspecific markers inflammatory response in bioprosthetic mitral valve recipients with calcific degeneration confirmed histological electron microscopic studies (group 1, n=22), those without 2, n=48).Patients bioprostheses were more likely to have a severe state (functional class IV 36% group 1 versus 15% P=0.03) longer cardiopulmonary bypass period (112.8±18.8 minutes 97.2±23.6 P=0.02) during primary surgery. Patients demonstrated moderate hypovitaminosis D (median 34.0, interquartile range [21.0; 49.4] vs 40 [27.2; 54.0] pmol/L, P>0.05), osteoprotegerin deficiency (82.5 [44.2; 115.4] 113.5 [65.7; 191.3] pg/mL, P>0.05) osteopontin (4.5 [3.3; 7.7] 5.2 [4.1; 7.2] ng/mL, significantly reduced bone-specific alkaline phosphatase isoenzyme (17.1 [12.2; 21.4] 22.3 [15.5; 30.5] U/L, P=0.01) interleukin-8 levels (9.74 [9.19; 10.09] pg/mL 13.17 [9.72; 23.1] P=0.045) compared an overall increase serum proinflammatory markers.Possible predictors include degree decompensated heart failure, duration invasiveness surgery, characteristics homeostasis recipient, defined bone resorption local systemic inflammation. The results confirm hypothesis that cell-mediated regulation pathological is dysregulation processes, which are turn controlled signals.