<p>Epigenetic Alterations of the Promoter Region of the <em>POMC</em> Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-injury Behaviors</p>

• DOI: 10.2147/prbm.s272445
• Publication Date: 2020-11-15T20:47:36Z
• Authors: Doudou Zheng; Xiaojiao Bi; Tianliang Zhang; Chao Han; Tantan Ma; Lina Wang; Mengmeng Sun; Kaiyan Cui; Limin Yang; Lanfen Liu
• Keywords: Depression

Purpose: The incidence of nonsuicidal self-injury (NSSI) behavior among adolescents increases year by year. Patients with a history both depression and NSSI behaviors tend to have greater risk suicide. At present, the mechanism adolescent depressive disorder patients is not clear, epigenetic may be involved. Proopiomelanocortin ( POMC ) gene associated disorder. purpose this study was investigate DNA methylation promoter region behaviors. Methods: Bisulfite Sequencing PCR (BSP) used test level 15 healthy controls (HC). Self-made questionnaires were collect clinical data case group control group. Hamilton scale-24 (HAMD-24), anxiety scale (HAMA), Symptom Checklist-90 (SCL-90) evaluate characteristics severity depressive, psychotic symptoms. Adolescent questionnaire assess its severity. Results: BSP analysis found that cytosine-guanine dinucleotide 1 (CpG1) site higher in than HC P < 0.05). significance at CpG1 between gender-independent, male 0.05) female HC. had little correlation trends family psychosis =0.05). We also CpG17 significantly Conclusion: There abnormal behaviors, act as markers for those adolescents. Keywords: adolescent, disorder, , methylation, Erratum paper has been published