Comparison of intra-arterial chemoembolization with and without radiotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: a meta-analysis

• DOI: 10.2147/tcrm.s126181
• Publication Date: 2016-12-22T15:55:44Z
• Authors: Qianqian Zhao; Kunli Zhu; Jinbo Yue; Zhonghua Qi; Shumei Jiang; Xiaoqing Xu; Rui Feng; Renben Wang
• Keywords: Transcatheter arterial chemoembolization; Portal vein thrombosis; Leukopenia

Numerous studies have tried to combine transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) with radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC) patients portal vein tumor thrombus (PVTT). However, efficacy TACE HAIC combined RT versus alone remains controversial. Thus, we performed a meta-analysis compare and safety intra-arterial HCC PVTT.PubMed, Embase, Cochrane Library databases were systematically searched eligible studies. Two authors independently reviewed abstracts, extracted relevant data rated quality The major end points objective response rate (ORR), overall survival (OS), adverse events.Eight total 1,760 included in this meta-analysis. pooled results showed that significantly improved ORR PVTT (OR, 4.22; 95% CI, 3.07-5.80; P<0.001) OS (HR, 0.69; 0.57-0.83; P=0.001), but did not affect primary liver 1.37; 0.67-2.79; P=0.390). incidence grade 3 4 leukopenia 5.80; 2.478-13.56; thrombocytopenia 3.77; 1.06-13.43; P=0.041) was higher plus group than group.Combination therapy could bring better benefits. This combination also associated increased risk events. they mostly mild moderate successfully treated conservative treatment.