In vitro antileishmanial and antioxidant activities of essential oils from different parts of Murraya paniculata (L.) Jack: a species of Rutaceae that occur in the Cerrado biome in Brazil

• DOI: 10.21475/ajcs.20.14.02.p1966
• Publication Date: 2020-04-10T20:57:09Z
• Authors: Flávia Fernanda A...; Cassia Cristina F...; Gabriel Almeida d...; Ana Carolina Bole...; Lizandra Guidi Ma...; Tatiana Manzini V...; Antônio Eduardo M...; Claudinei Alves d...; Mayker Lazaro Dan...
• Keywords: Murraya; Phenylpropanoid

In Brazilian folk medicine, Murraya paniculata has been used for treating intestine disorders, rheumatism and cough. This paper aims to investigate the in vitro antileishmanial antioxidant activities of essential oils (EO) from M. leaves fruits (ripe unripe ones). Natural antioxidants may be very beneficial improve quality life, since they are capable protecting body against damage caused by free radicals and, consequently, either preventing or postponing many diseases starting their cycles. One techniques which widely detecting compounds is method based on elimination stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•). It considered easy, precise, fast, simple, economical appropriate determine activity pure substances complex mixtures, such as EO. Thus, potential EO was evaluated using exhibited weak potential, EC50 values were above 700 µg/mL. Several reports have stated that volatile plants show promising leishmanicidal promastigote forms Leishmania amazonensis; relation this activity, leaf oil highly active (IC50 = 7.33±2.07 µg/mL) while ripe fruit active, with IC50 30.77±2.07 µg/mL 13.04±1.64 µg/mL, respectively. Both GC-FID GC-MS analyses revealed major components determined sesquithujene (25.0%), trans-β-caryophyllene (23.8%), α-zingiberene (21.0%), α-ylangene (13.3%), germacrene D (13.1%), α-copaene (12.7%), β-cubebene (10.2%). also described first time.