Selenoacetylenes Protect against Beta-Amyloid Peptide-Induced Paralysis and Promote Longevity in Caenorhabditis elegans

• DOI: 10.21577/0103-5053.20240131
• Publication Date: 2024-07-22T13:32:16Z
• Authors: Maria Isabela Fig...; Ivani Mello; Sabrina Targanski; Juliana Duarte; Leonardo Vasconcelos; André Luiz Stein; Marcos Antonio So...
• Keywords: Amyloid (mycology)

Selenium-containing compounds exhibit diverse biological activities, such as antioxidative, anti-inflammatory, and cancer preventive effects. Using Caenorhabditis elegans a model organism, we assessed the toxicity, neuroprotective, antioxidant properties, impact on longevity of 11 selenoacetylenes. Their toxicity bioactivities varied based molecular structure. Selenoacetylenes with butyl substituents were toxic to Galleria mellonella larvae. The presence but-3-in-2-ol radical increased antiprotozoal activity against Tetrahymena pyriformis. Compared positive control (Nimitz® EC), selenoacetylenes less nematode worms eggs. significantly reduced amyloid beta (Aβ) paralysis in C. CL4176 worms, by 18 22%, along improving survival after oxidative or thermal stress. Galantamine, showed inferior results. These findings enhance our understanding neuroprotection, activity, elegans. Future mammalian studies will further elucidate mechanisms explore potential therapeutic use treating Alzheimer’s disease longevity.