Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo

• DOI: 10.21608/bjas.2021.188825
• Publication Date: 2021-09-01T19:38:30Z
• Authors: K.M. Hussein; N.E. Sorour; N.F. Alhusseini; A.G. Abdou; A.y. Habashy
• Keywords: Vitiligo; Microphthalmia-associated transcription factor; Pigmentation disorder; Melanocyte; Melanocyte-stimulating hormone

Background: Vitiligo is a complicated, multifaceted condition of the skin.Abnormalities in surrounding keratinocytes may lead to death melanocytes because growth factors are deprived.Ultraviolet band B (NB-UVB) successful treatment option particularly generalised individuals.Objective: The purpose this research was assess lesional skin vitiligo patients levels microphthalmia-associated transcription factor (MITF), alpha melanocyte stimulating hormone and isocitrate dehydrogenase 2 (IDH2) influence NBUVB on them.Methods: 25 have been enrolled.They got twice weekly for total 20 sessions non-consecutive days.Each patient received biopsies from before after treatment.Results: 10% had great clinical response treatment; showed fair response; 40% moderate reactions; 35% poor 5% exhibited advancing illness.Conclusion: NB-UVB an effective means treating vitiligo, by upregulating α MSH, master regulator melanogenesis.