Modulatory Role of Zeolite against Cadmium Chloride-Induced Renal Damage In Pregnant Rats and Their Fetuses

• DOI: 10.21608/eajbsz.2024.352274
• Publication Date: 2024-05-08T08:52:22Z
• Authors: Nehad Ibrahim; Asmaa Kandil; Rania Ali; Hanan Ahmed; Rania Yahia
• Keywords: Cadmium chloride; CADMIUM EXPOSURE

Cadmium (Cd) is a heavy metal and significant inorganic toxin that commonly found throughout the environment. The human body, as well kidneys, tend to accumulate Cd. Research conducted on both humans animals suggests exposure cadmium can lead skeletal damage, specifically osteoporosis. Based prevalence of in environment its frequent use, we studied effect toxicity pregnant rat their fetuses zeolite them. experimental rats were divided into 5 groups (n=8, each). 1st group received distilled water normal control group. 2nd tween80 served 3rd was administrated with dissolved tween80then at dose (100mg\kg\day). 4th chloride (30mg\kg\day). 5th combination chloride. All administered materials orally from 6th day 15th gestation. sacrificed end gestation periods (on 20th day). Our obtained results showed adverse histological alterations maternal fetal kidneys. Also, CdCl2 (cadmium chloride) induced remarkable changes levels kidney functions. On other hand, incomplete ossification skull, metacarpals, phalanges toes fetuses' skeletons. Zeolite administration markedly ameliorated altered renal physiological deformity by cadmium.