Quorum Sensing and Some Promising Virulence Inhibitors in Pseudomonas aeruginosa

• DOI: 10.21608/odr.2022.154964.1006
• Publication Date: 2022-08-18T20:37:38Z
• Authors: Moustafa Saleh
• Keywords: 0301 basic medicine; 03 medical and health sciences

Pseudomonas aeruginosa is a Gram-negative bacterium frequently found in clinical specimens of hospitalized patients, mainly those with suppressed immune systems.It one the topmost ubiquitous nosocomial pathogens humans and considered life-threatening.Pseudomonas chief causative agent pneumonia, urinary tract infections, surgical site burns infections immunosuppressed patients.Pyocyanin, pyoverdin, exotoxin-A, rhamnolipids, protease enzymes are only few virulence factors produced by that contribute to its pathogenesis.Long-term treatment antimicrobial agents resulted development multi-drug resistant strains, which highly complicated be treated.Therefore, there great interest discovering innovative strategies for managing MDR aeruginosa.Quorum sensing inhibitors offer substitutional policy combat microbial infections.This depends on disarming attenuating production regulated quorum eliminating pathogen's capacity harm host.It anticipated could valuable treating caused acting as adjuvants or alternatives conventional antibiotics.The strategy finding beginning produce promising outcomes.