Investigation of the effect of Severe Acute Respiratory Syndrome Coronavirus 2 pandemic on autoantibody

• DOI: 10.21673/anadoluklin.1490524
• Publication Date: 2024-07-29T14:01:58Z
• Authors: Zeynep Dilara Kar...; Emel Çalışkan; Emel Akbaş; Şükrü Öksüz; İdris Şahin
• Keywords: Pandemic; Immunofluorescence

Aim: The aim of this study is to determine the possible relationship between SARS-CoV-2 infection and systemic or organ-specific autoimmune diseases. Methods: Serum samples sent Medical Microbiology Laboratory from patients in various clinics with suspicion disease March 2018 2022 were included our study. During period, results whose indirect immunofluorescence antibody parameters examined laboratory obtained automation system hospital evaluated retrospectively. Results: In two years before COVID-19 pandemic during 2256 who positive for any autoantibody among 8325 referred IIFA. A total 2448 anti-nuclear patterns identified, 2038 which single pattern (1363 speckled) 218 multiple patterns. When change positivity over time was examined, it determined that there a statistically significant increase rates ANA, anti-dsDNA, anti-ICA anti-Gliadin autoantibodies first compared previous years. No difference observed AMA, ASMA, anti-Endomysium, ANCA all periods pandemic. Conclusion: anti-ICA, period suggested process may trigger aggravate some