Histoplasmose disseminada em canino urbano com acesso ao ambiente rural

• DOI: 10.21708/avb.2024.18.1.11852
• Publication Date: 2024-06-04T23:17:21Z
• Authors: Paula Michelson V...; Ezequiel Davi dos...; Rúbia Schallenber...; Bibiana da Rosa P...; Aline Bielak dos ...; Adriana Costa da ...
• Keywords: Langhans giant cell; Mesenteric lymph nodes

Histoplasmosis is a systemic disease caused by the fungus Histoplasma capsulatum. The microorganism causes localized granulomatous disease, with respiratory tract being most affected, and can spread through lymphatic blood stream. Severe infection in dogs associated immunosuppressive therapies. reported case occurred canine, brought to care serious clinical condition, which did not respond treatment was euthanized. necropsy examination showed white nodules, of firm consistency distributed throughout omentum, liver, splenic capsule, pancreas, stomach serosa, intestines, bladder, mesenteric inguinal lymph nodes, diaphragm, parietal pleura, aorta aortic lunate. Microscopically, all nodular lesions consisted areas necrosis, intense histiolymphoplasmacytic infiltrate, epithelioid macrophages Langhans-type giant cells yeast-like structures, morphology arrangement consistent spp., confirmed special Periodic Acid-Schiff (PAS) stains Grocott. Therefore, present study aims describe multisystemic histoplasmosis diagnosed anatomopathology histochemistry, alert this potential urban canines access rural and/or environments fungal agent.