Safety Analysis and Improved Cardiac Function Following Local Autologous Transplantation of CD133+ Enriched Bone Marrow Cells After Myocardial Infarction

• DOI: 10.2174/156720207781387141
• Publication Date: 2007-07-29T19:53:14Z
• Authors: Hossein Ahmadi; Saeed Kazemi Ash...; Massoud Soleimani; Hakimeh Sadeghian; Jalil Madjd Arde...; Narges Zare Mehr...; Azam Kouhkan; Mehrnaz Namiri; Manouchehr Madan...; Fatemeh Fattahi; Abdolhossein Sha...; Ahmad Vosough Di...
• Keywords: 0303 health sciences; Myocardial Infarction; Bone Marrow Cells; Cell Count; Transplantation, Autologous; 3. Good health; 03 medical and health sciences; Treatment Outcome; Antigens, CD; Humans; AC133 Antigen; Prospective Studies; Peptides; Bone Marrow Transplantation; Follow-Up Studies; Glycoproteins; Retrospective Studies

The CD133(+) bone marrow cell (BMC) population includes primitive multipotent stem cells which induce neoangiogenesis. Studies suggested transplantation of these to infarcted myocardium can have a favorable impact on tissue perfusion and contractile performance. We assessed the feasibility, safety functional outcomes autologus BMC during coronary artery bypass grafting (CABG) in patients with recent myocardial infarction. In prospective, nonrandomized, open-label study, 27 infarction underwent CABG intramyocardial injection autologous marrow-derived (18 patients, group) or alone (9 control group). At 6 months after CABG, Wall Motion Score Index (WMSI) was significantly reduced for akinetic/dyskinetic segments treated compared group (P<0.006). Likewise, comparison between baseline follow up results dobutamine stress echocardiography scintigraphy showed improvement viability local zone group. No complications related were noted, either procedurally postoperative at mean 14 up. infarction, peri-infarct surgery is feasible safe, no evidence early late adverse events. Moreover, might restore improve myocardium, suggesting that they may myogenesis as well angiogenesis.