PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury

• DOI: 10.2174/156720212799297100
• Publication Date: 2012-02-10T19:26:27Z
• Authors: Koichi Arimura; Tetsuro Ago; Masahiro Kamouchi; Kuniyuki Nakamura; Koji Ishitsuka; Junya Kuroda; Hiroshi Sugimori; Hiroaki Ooboshi; Tomio Sasaki; Takanari Kitazono
• Keywords: Pericyte; Platelet-derived growth factor

Platelet derived growth factor (PDGF)-B plays a neuroprotective role in brain damages, including ischemic stroke. It has been suggested recently that PDGF receptor β (PDGFRβ) expressed pericytes as well neurons and astrocytes may mediate the of PDGF-B. The aims this study were to elucidate roles PDGFRβ signaling after In rat middle cerebral artery occlusion (MCAO) model, expression was induced specifically peri-infarct areas its level gradually increased. PDGF-B marked phosphorylation Akt cultured pericytes. Consistently, upregulated endothelial cells per-infarct strongly phosphorylated PDGFRβ-expressing periinfarct MCAO. pericytes, cell anti-apoptotic responses through Akt. Furthermore, significantly increased nerve (NGF) neurotrophin-3 (NT- 3) Thus, PDGFRβ-Akt play various important leading neuroprotection Keywords: angiogenesis, blood barrier, cells, microvascular, PI3K, Cell Signaling Technology, qPCR RT kit, LightCycler, SYBR, neurotrophic factor, Apoptosis, growth, stroke, neuroprotection, neurotrophins, pericyte, PDGF-B,