Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging

• DOI: 10.2174/1567202611666140829161410
• Publication Date: 2014-10-18T04:44:48Z
• Authors: Maria Lagana; Anamika Chaudhary; Deepa Balagurunathan; David Utriainen; Paul Kokeny; Wei Feng; Pietro Cecconi; David Hubbard; E. Haacke
• Keywords: Magnetic resonance angiography; Outflow

We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular veins (IJV) for 92 patients multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify of CSF and major vessels (including IJV carotid arteries) C2-C3 neck. Contrast enhanced MR angiography time-of-flight venography were subdivide MS into stenotic (ST) non-stenotic (NST) populations. evaluated: normalized by arterial flow; peaks; outflow duration its onset from systole. tested if these variables statistically different among phenotypes between ST NST patients. The delay beginning systole higher compared MS. Less observed vs None measures phenotypes. These results suggest that alterations morphology affect both timing but not amplitude.