Impaired Translation of Spatial Representation in Young Onset Alzheimer’s Disease Patients

• DOI: 10.2174/1567205011310010013
• Publication Date: 2013-02-15T10:02:49Z
• Authors: Ming-Chyi Pai; Ya-Chi Yang
• Keywords: Retrosplenial cortex; Representation

Many early-stage Alzheimer's disease (AD) patients suffer from spatial navigational impairment even in familiar environments. Growing evidence shows that the retrosplenial cortex (RSC) is more damaged young-onset AD (YOAD, onset age before 65) than late-onset (LOAD) of AD. Impaired translation between egocentric and allocentric representations environment, as a cause for impairment, usually occurs people with lesions RSC.To test translational ability YOAD LOAD patients.Tests deemed sensitive to were used evaluate 29 (14 YOAD, 15 LOAD) 27 cognitively healthy controls younger NC 13 older NC).Younger outperformed tests spite their equal basic visuoperceptual abilities distance estimation. No such difference existed NC.The egocentric-allocentric representation ability, principal function RSC, does not deteriorate equally different age. That show deviations deserves our attention because it may endanger daily activities.