Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

• DOI: 10.2174/1567205011310040008
• Publication Date: 2013-04-25T05:31:52Z
• Authors: Lixi Li; Sufang Zhang; Xin Zhang; Ting Li; Yu Tang; Hui Liu; Wendi Yang; Weidong Le
• Keywords: Neuropathology; Amyloid beta; Memory Impairment

Autophagy plays an important role in Alzheimer's disease (AD). It has been reported that autophagic flux is altered patients with AD, and application of the autophagy enhancer rapamycin may alleviate cognitive impairment amyloid-β (Aβ) neuropathology transgenic animal model AD. Since also immune suppressor, there a concern long-term use bring severe unwanted side effects. The aim this study to test if carbamazepine (CBZ), anti-epileptic drug potent enhancement effect, anti-AD effects APPswe/PS1deltaE9 mice We found display increased activity accompanied by decreased mTOR activity. After three months treatment CBZ mice, we demonstrated spatial learning memory deficits these are significantly alleviated. documented cerebral amyloid plaque burden Aβ42 levels reduced. Furthermore, showed enhances which unlikely via mTOR-dependent pathway. These data suggest have protective effect AD mouse possibly through enhancing flux. Keywords: Amyloid-β, disease, autophagy, carbamazepine, pathway,