Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer’s Disease: A Reproducible Study

• DOI: 10.2174/1567205012666150710111615
• Publication Date: 2015-11-20T08:13:08Z
• Authors: Xiuchao Sui; Maohu Zhu; Yue Cui; Chunshui Yu; Jing Sui; Xinqing Zhang; Jieqiong Liu; Yunyun Duan; Zengqiang Zhang; Luning Wang; Xi Zhang; Tianzi Jiang
• Keywords: Male; Rest; Resting state functional MRI; Datasets as Topic; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Alzheimer Disease; Neural Pathways; Humans; Cognitive Dysfunction; Aged; Brain Mapping; Mild cognitive impairment; Brain; Biomarker; Alzheimer's disease; Classification; Magnetic Resonance Imaging; 2808 Neurology; Functional connectivity density; Female; 2728 Clinical Neurology; Mental Status Schedule

Cortical hubs that link functionally specialized neural systems are crucial for cognition. Evidence suggests the location and organization of related to Alzheimer's disease (AD). However, two issues remain unclear: (i) where how change in AD, (ii) whether could be a potential pre-diagnosis biomarker mild cognitive impairment (MCI) - prodromal phase AD. Accordingly, we examined functional connectivity density (FCD) cohorts resting-state magnetic resonance imaging (fMRI) scans (26 27 controls; 33 21 controls) revealed consistently vulnerable FCD hub regions AD compared with controls: within default mode network, short-range decreases posterior cingulate cortex increases medial prefrontal cortex; frontal lobe, long-range cortex, superior gyrus middle gyrus. Furthermore, correlates score distinguish MCI from controls high accuracy (71.08% dataset 1, 81% 2). By reflecting robust reproducible global shift brain functions, provides an fMRI underlying mechanism Keywords: disease, biomarker, classification, density, impairment, resting state MRI.