Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

• DOI: 10.2174/1570178043400929
• Publication Date: 2005-03-18T04:24:15Z
• Authors: Martin Brunner; Thomas Straub; Pauli Saarenketo; Kari Rissanen; Ari Koskinen
• Keywords: Absolute Configuration

Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine- 3,4-dicarboxylate (1a / b) is reported. The relative absolute configuration the methylated products was assigned by NOESY confirmed a crystal structure 1a. Keywords: amino acids, alkylation, diastereoselectivity