Total Synthesis of (±)-Euryfuran Through Ti(III) Catalyzed Radical Cyclization

• DOI: 10.2174/157017807782795457
• Publication Date: 2007-11-29T20:29:51Z
• Authors: Antonio Rosales; Cristobal Lopez-S...; Miriam Alvarez-Co...; Manuel Muooz-Dorado; Ignacio Rodriguez...
• Keywords: Radical cyclization

A concise total synthesis of the furano-sesquiterpene (±)-euryfuran, a bioactive metabolite from some marine sponges, is presented. The key step highly diastereoselective titanium (III) catalyzed radical cyclization farnesol epoxyderivative. Keywords: Titanium, reactions, cyclization, diastereoselectivity, farnesol, furanosesquiterpenes