Influence of Coronary Artery Stenosis Severity and Coronary Collateralization on Extent of Chronic Myocardial Scar: Insights from Quantitative Coronary Angiography and Delayed-Enhancement MRI

• DOI: 10.2174/1874192400802010079
• Publication Date: 2008-10-15T11:42:10Z
• Authors: Daniel Bexell; Randolph M Setser; Paul Schoenhagen; Michael L Lieber; Sorin J Brener; Thomas B Ivanc; Eva M Balazs; Thomas P O`Donnell; Arthur E Stillman; Håkan Arheden; Galen S Wagner; Richard D White
• Keywords: Collateralization

Objectives: In patients with chronic ischemic heart disease, the relationship between coronary artery lesion severity and myocardial scarring is unknown.The purpose of this study was to examine proximal stenosis severity, amount collateralization, scar extent in distal distribution affected based on both quantitative angiography (QCA) delayed-enhancement magnetic resonance imaging (DE–MRI). Methods: Thirty-four (26 males, 8 females; age range: 35-86 years) a containing single, ≥30% by underwent DE-MRI. The morphology (area, transmurality patchiness) examined using linear mixed-model ANCOVA. Results: There statistically significant correlation (r=0.53, p<0.01). Patients hemodynamically stenoses (≥70%) exhibited significantly greater collateralization (p<0.05) (p<0.01) than <70% stenosis. However, often found <70%. Also, (93±14%) mean (41±35%) were collaterals without (diameter 48±10%, p<0.01) (scar 19±29%, p=0.01). Conclusions: Using QCA DE-MRI, we demonstrate extent, absence documented history acute infarction. likely reflects increasing ischemia leading formation range angiographically observed stenosis, especially females.