Complex 3D Models to Study Drug Targeting of Invadopodia

• DOI: 10.2174/2212697x113016660003
• Publication Date: 2014-06-13T04:31:42Z
• Authors: Njainday Jobe; Daniel Rosel; Ondrej Tolde; Jan Kosla; Jan Brabek
• Keywords: Invadopodia

Metastasis is the main cause of death in cancer patients, and spite its significance, it still incompletely understood. In order for to be metastatic, must undergo a sequence events, termed as metastatic cascade. The ability cells migrate invade surrounding tissue critical step metastasis often associated with formation specific cellular structures called invadopodia. Invadopodia are actin-based protrusions tumour or transformed critically involved protease secretion targeting, cytoskeletal rearrangements enabling invasion. Anti-invadopodia therapy possible new field anti-metastatic treatment. We propose here novel model drug discovery anti-invadopodial compounds based on large scale screening invadopodia 2D setting followed by validation results complex 3D matrices such dermis-based matrix. Keywords: Cancer, development, invadopodia, invasiveness, metastasis, 3D, matrices.