A Rare Case of Giant Congenital/Infant-type Hemispheric Glioma Harboring Concomitant ALK and EGFR Alteration

• DOI: 10.2176/jns-nmc.2023-0286
• Publication Date: 2025-03-06T22:15:27Z
• Authors: Derya KARATAS; Saygi UYGUR; Irmak Tekeli BARUT; Hamide SAYAR; Ahmet DAGTEKIN; Emel AVCI
• Keywords: Concomitant

Infant-type hemispheric glioma is a subtype of pediatric high-grade that seen among those under the age 3-5 years and congenital infant-type gliomas are another which 6 months age. The molecular features overall survival distinct from adult gliomas. present study reports fraternal twin case giant diagnosed at 2 treated with gross total resection. Even though Ki-67 proliferative index tumor was 70%, she has been surviving for 4 years. After analysis, first had concurrent echinoderm microtubule-associated protein-like 4::anaplastic lymphoma kinase gene fusion an A269V point mutation on exon 7 in epidermal growth factor receptor identified. Among cases, presents rare long recurrence-free without radiation or targeted therapy. In contrast, neurocognitive test results this corresponded to 12-15