Ectopic Myoglobin Expression Is Associated with a Favourable Outcome in Head and Neck Squamous Cell Carcinoma Patients

• DOI: 10.21873/anticanres.11217
• Publication Date: 2017-01-01T18:49:43Z
• Authors: SEBASTIAN MELLER; ANNE VAN ELLEN; HEIDRUN GEVENSLEBEN; ANNE BICKER; THOMAS HANKELN; THOMAS GORR; VERENA SAILER; FREYA DRÖGE; FRIEDERIKE SCHRÖCK; FRIEDRICH BOOTZ; ANDREAS SCHRÖCK; SVEN PERNER; DIMO DIETRICH; GLEN KRISTIANSEN
• Keywords: Tissue microarray; Ectopic expression

Ectopic myoglobin (MB) expression, mediated by alternative and hypoxia-inducible transcription, has recently been demonstrated in several epithelial tumours. This study aimed to examine the expression of MB hormone-independent head neck squamous cell carcinomas (HNSCCs).Using imunohistochemistry, ectopic was analyzed on tissue microarrays (TMAs) 524 patients with localized locally advanced primary recurrent HNSCC who had undergone surgical treatment curative intent. Associations survival clinicopathological parameters were analyzed.MB found 45.8% being significantly lower normal adjacent (NAT) compared tumours (p<0.001) associated a favourable overall (OS) [p=0.037, hazard ratio (HR)=0.72, 95% confidence interval (CI)=0.53-0.98]. Furthermore, negatively correlated human papillomavirus (HPV) status (p=0.013).MB is differentially expressed correlates better OS.