Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma

• DOI: 10.21873/anticanres.11230
• Publication Date: 2017-01-01T18:49:43Z
• Authors: KYOICHI OBATA; TSUYOSHI SHIMO; TATSUO OKUI; KENICHI MATSUMOTO; HIROYUKI TAKADA; KIYOFUMI TAKABATAKE; YUKI KUNISADA; SOICHIRO IBARAGI; HITOSHI NAGATSUKA; AKIRA SASAKI
• Keywords: 0301 basic medicine; 03 medical and health sciences; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Receptors, Neurokinin-3; Receptors, Tachykinin; 3. Good health

Background: Tachykinin 3 (TAC3) and its preferred tachykinin receptor (TACR3) that are prominently detected in the central nervous system, play significant roles physiological development specifically human reproductive system. The of TAC3/TACR3 oral squamous cell carcinoma unknown. Materials Methods: We examined expression pattern clinically-resected samples using immunohistochemistry immunofluorescence analysis. Results: found even though level TACR3 was negative normal epithelium, it highly elevated tumor cells. A more intense signal observed invasive front cells had migrated into mandible bone matrix. TAC3 not cells, but expressed PGP-9.5-positive sensory nerves mandible. Conclusion: Our results suggest peripheral nerve-derived may affect gingival through